Msxnaengine.dll 1
Msxnaengine.dll 1
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Msxnaengine.dll 1
How to fix: This file cannot be uploaded because it is too large.. We are working on improving our service. Please try again later. MySpace Video 2 Final Cut Pro.Ara-C (cytarabine) immunochemotherapy in patients with newly diagnosed acute non-lymphoblastic leukemia (ANLL): a multicentre randomized study. Deauville 2000 Study Group.
This multicentric randomized study compared three different chemotherapy regimens combined with granulocyte colony-stimulating factor (G-CSF) in 375 patients with ANLL. Treatment consisted of daunorubicin (DNR) and Ara-C (cytarabine) in 280 patients, of DNR, cyclophosphamide (CTX) and Ara-C (caravelle) in 76 patients, and of DNR, etoposide (VP-16), Ara-C (cytarabine) and G-CSF in 19 patients. Patients achieving complete remission (CR) were randomized to maintenance therapy with either oral 6-mercaptopurine (6-MP) and methotrexate (MTX) alone (n = 149) or oral 6-MP and MTX plus local high-dose Ara-C (Ara-C HDT) (n = 150). Event-free survival (EFS) was the primary end-point of the study; event-free survival and overall survival (OS) were analyzed in intent-to-treat and in patients in CR at transplantation. In CR patients, the probabilities of EFS were 22% (DNR-Ara-C), 17% (DNR-CTX-Ara-C) and 19% (DNR-VP16-Ara-C) at 24 months (P = 0.267). The probability of EFS at 30 months was 10% (all arms). The probability of survival at 24 months was 50%, 36% and 44% (P = 0.051), and 40% and 45% (P = 0.19) at 48 months. The probability of a second CR was 55%, 50% and 63% (P = 0.089) in the 3 arms. The EFS and survival probabilities were superior in all arms when patients in first CR at transplantation were compared with those transplanted in CR1 at relapse (P = 0.001). The addition of Ara-C HDT did not improve significantly EFS in
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